Nick Mangold, the former New York Jets star center and two-time All-Pro, has tragically passed away at the age of 41 due to complications from kidney disease. The Jets legend had been publicly seeking a kidney donor after revealing his battle with chronic kidney failure earlier this month.

Mangold, who spent his entire 11-year NFL career with the Jets, was undergoing dialysis while awaiting a transplant. His sudden passing has sent shockwaves through the football community, leaving fans and former teammates mourning the loss of one of the franchise’s most beloved players.

The Ohio State alum had been diagnosed with a genetic kidney defect in 2006, which ultimately led to his health struggles. Despite his courageous fight, Mangold’s condition deteriorated rapidly in recent weeks.

Nick Mangold Death Cause and Kidney Transplant Timeline: How Did the Jets Legend Pass Away at 41?

What genetic disease caused Nick Mangold’s kidney failure?

Nick Mangold revealed in October 2025 that a genetic defect diagnosed in 2006 led to his chronic kidney disease. While the specific condition wasn’t disclosed, such cases often involve polycystic kidney disease or Alport syndrome – hereditary disorders that gradually impair kidney function. The former Jets center had been managing the condition for nearly two decades before his health rapidly declined in summer 2025, requiring dialysis and ultimately a transplant.

The silent progression of genetic kidney diseases makes them particularly dangerous. Many athletes like Mangold may not realize the severity until organ damage is advanced.

That’s terrifying! Do teams perform genetic testing for conditions like this during player physicals?

Why couldn’t family members donate a kidney to Nick Mangold?

Mangold’s public appeal for a type O blood donor suggested his family members weren’t compatible matches. Kidney transplants require:

• Blood type compatibility
• Tissue match (HLA antigens)
• Negative crossmatch (no antibodies against donor)

Given the genetic nature of his condition, relatives may have carried the same mutation or simply not met the stringent medical criteria. The wait for a deceased donor kidney averages 3-5 years, creating urgent need for living donors.

How common is kidney disease among NFL players?

The NFL has seen several cases of kidney failure, often attributed to:

What were Nick Mangold’s final days like?

After going public with his need for a transplant on October 14, Mangold remained active on social media, thanking supporters. Reports indicate his condition deteriorated rapidly in late October from complications possibly including:

• Sepsis from dialysis access infections
• Cardiac events common in end-stage renal disease
• Electrolyte imbalances

The athletic build that served him during 11 NFL seasons may have worked against him – muscular individuals often struggle with dialysis adequacy.

How many NFL players have died from kidney disease?

While rare, several NFL players have faced kidney-related deaths:

• Reggie White (sleep apnea complication)
• Thomas Herrion (kidney failure post-game)
• Several former players in renal failure from painkiller abuse

Mangold’s case stands out as one of the youngest high-profile kidney disease fatalities at just 41. The sports world typically sees more cardiac or neurological causes of death.

Could better screening have saved Mangold?

Even with earlier detection, genetic kidney diseases often progress inevitably. The real opportunity was finding a living donor sooner – every month on dialysis increases mortality risk by 5-10%.

It’s heartbreaking that such a beloved player couldn’t get a transplant in time. This should spark more awareness about living donation.

What’s Nick Mangold’s legacy beyond football?

The seven-time Pro Bowler’s final act – publicly seeking a donor – may save countless lives by:

• Increasing kidney disease awareness
• Demonstrating athletes’ vulnerability to “silent” conditions
• Inspiring organ donor registrations

New York Jets owner Woody Johnson praised Mangold’s courage in using his platform to help others facing similar battles.

Are former Jets teammates planning memorial tributes?

While official plans haven’t been announced, several teammates shared emotional tributes suggesting:

• Potential retired number consideration
• Fundraisers for kidney research
• Annual health screenings in Mangold’s name

The Jets organization has reportedly begun discussions with Mangold’s family about appropriate honors for one of their most decorated players.